Luckily we didn't have a car while in the downtown area of San Francisco! We had rented a car at the airport (3-hour ordeal!!) to tour Napa Valley. Powell Place has no parking but you could call them for local parking options possibly with their pre-arranged discount!?! As another consideration, there are shuttle services to/from the airport for reasonable fees (~$15/person). Perhaps, you could park in proximity (free?) to the airport and shuttle, depending upon alternative parking costs and length of stay. Powell Place is well situated on cable car route and a nice place! Enjoy and safe travels!